Risk Assessment in Drug Hypersensitivity: Detecting Small Molecules Which Outsmart the Immune System
Drug hypersensitivity (DH) reactions are clinically unusual because the underlying immune stimulations are not antigen-driven, but due to non-covalent Office Desk drug-protein binding.The drugs may bind to immune receptors like HLA or TCR which elicits a strong T cell reaction (p-i concept), the binding may enhance the affinity of antibodies (enhan